The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

LVII.c

BAL: An excess proportion of eosinophils

Publications

Utley LM, Larsen S, Goldberg T, Barjasteh T

Daptomycin and acute lung injury: recognising drug-induced eosinophilic pneumonia.

BMJ case reports 2025 Jul 18;18; — 2025 Jul 18

Pham TT, Garreau R, Craighero F, Cottin V, Said BB, Goutelle S, Ferry T

Seventeen Cases of Daptomycin-Induced Eosinophilic Pneumonia in a Cohort of Patients Treated for Bone and Joint Infections: Proposal for a New Algorithm.

Open forum infectious diseases 2022 Nov;9;ofac577 — 2022 Nov — ofac577

Storandt MH, Matta A

Acute Eosinophilic Pneumonia: A Rare Complication of Daptomycin Therapy.

Cureus 2020 Jan 28;12;e6803 — 2020 Jan 28 — e6803

Raza A, Arslan A, Atiq MU, Chan V, Patel RK

Unexpected Outcome of Daptomycin-induced Eosinophilic Pneumonia: Rarity Within a Rarity.

Cureus 2019 Dec 02;11;e6271 — 2019 Dec 02 — e6271