The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

IV.k

Bronchiectasis

Notable in patients with rituximab-induced hypogammaglobulinemia where lung changes may resemble those in CVID

Publications

AlHarbi N, AlEidan A, AlZanbagi MA

Reversible Rituximab-Induced Bronchiectasis: A Pediatric Case Report and Literature Review.

The American journal of case reports. 2026;27:e952043

Farhat L, Dara J, Duberstein S, De A

Secondary Hypogammaglobulinemia After Rituximab for Neuromyelitis Optica: A Case Report.

Drug safety - case reports. 2018;5(1):22