The Drug-Induced Respiratory Disease Website and App
Frequency - Incidence
Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases
Evidence level/grade
Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic
Bronchospasm - Wheezing - Asthma
Publications
Airway spasm or collapse? An alternate mechanism of action for an important side effect of Sildenafil warrants consideration in patients with tracheobronchomalacia.
The Journal of pediatrics 2019 Jul 03;; — 2019 Jul 03
Sildenafil Use in Children with Pulmonary Hypertension.
The Journal of pediatrics 2019 Feb;205;29-34.e1 — 2019 Feb — 29-34.e1