The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

I.a

Pneumonitis (interstitial lung disease/ILD)

Publications

Matijasic N, Bonevski A, Tokic Pivac V, Pavic I

Busulfan-Induced Lung Injury in Pediatric Oncology Patients-Review of the Literature with an Illustrative Case.

Pediatric allergy, immunology, and pulmonology 2019 Sep 01;32;86-91 — 2019 Sep 01 — 86-91

Oakhill A, Green ID, Knowlson GT, Cameron AH, Shah KJ, Hill FG, Mann JR

Busulphan lung in childhood.

Journal of clinical pathology 1981 May;34;495-500 — 1981 May — 495-500