The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

XLII.a

Alveolar hemorrhage (AH), diffuse AH (DAH)

Publications

?lhan E, Güvenç TS, Güzelburç Ö, Altay S, Özer N, Soylu Ö, Hasdemir H, Ergelen M

A fatal complication of tirofiban in an octogenarian: Diffuse alveolar hemorrhage.

Journal of cardiology cases 2010 Aug;2;e48-e51 — 2010 Aug — e48-e51

Zhou X, Peng H, Yin Y, Huang H, Zeng J, Ouyang F

Diffused alveolar hemorrhage: A rare and severe complication of tirofiban-induced thrombocytopenia.

International journal of cardiology 2016 Mar 01;206;93-4 — 2016 Mar 01 — 93-4

?arl? B, U?urlu M, Tok A, Dondurmac? E, Sa? Ertürk F

A misleading diagnosis in acute coronary syndrome: tirofiban-induced alveolar hemorrhage.

Turk Kardiyoloji Dernegi arsivi : Turk Kardiyoloji Derneginin yayin organidir 2015 Dec;43;753 — 2015 Dec — 753

Guo J, Xu M, Xi Y

Tirofiban-induced diffuse alveolar hemorrhage: after primary angioplasty.

Texas Heart Institute journal 2012;39;99-103 — 2012 — 99-103

Gill DS, Ng K, Ng KS

Massive pulmonary haemorrhage complicating the treatment of acute coronary syndrome.

Heart (British Cardiac Society) 2004 Mar;90;e15 — 2004 Mar — e15

Yilmaz MB, Akin Y, Biyikoglu SF, Guray U, Korkmaz S

Diffuse alveolar hemorrhage following administration of tirofiban in a patient with acute coronary syndrome: a fatal complication.

International journal of cardiology 2004 Jan;93;81-2 — 2004 Jan — 81-2

Ali A, Patil S, Grady KJ, Schreiber TL

Diffuse alveolar hemorrhage following administration of tirofiban or abciximab: a nemesis of platelet glycoprotein IIb/IIIa inhibitors.

Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions 2000 Feb;49;181-4 — 2000 Feb — 181-4