The Drug-Induced Respiratory Disease Website and App
Frequency - Incidence
Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases
Evidence level/grade
Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic
Imaging: Lung nodule or nodules
May correspond to MTX-associated pulmonary nodulosis (see under Iq) or lymphoproliferative disease (PMID 30739816)
Publications
Makihara S, Kariya S, Noujima-Harada M, Ohara N, Naito T, Matsumoto J, Noda Y, Okano M, Yoshino T, Nishizaki K
Methotrexate-associated lymphoproliferative disorder with multiple pulmonary nodules and bilateral cervical lymphadenopathy.
Auris, nasus, larynx 2019 Feb 07;; — 2019 Feb 07
Multiple pulmonary nodules in a male with psoriatic arthritis.
European respiratory review : an official journal of the European Respiratory Society 2010 Jun;19;164-5 — 2010 Jun — 164-5