The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

I.m

Diffuse alveolar damage (DAD) (see alsoo under IIb and XVf)

Publications

Seto T, Seki N, Uematsu K, Tanigaki T, Shioya S, Koboyashi T, Umemura S, Eguchi K

Gefitinib-induced lung injury successfully treated with high-dose corticosteroids.

Respirology (Carlton, Vic.) 2006 Jan;11;113-6 — 2006 Jan — 113-6

Aoe K, Hiraki A, Murakami T, Maeda T, Umemori Y, Katayama H, Eda R, Takeyama H

Sudden onset of interstitial lung disease induced by gefitinib in a lung cancer patient with multiple drug allergy.

Anticancer research 2005 Jan-Feb;25;415-8 — 2005 Jan-Feb — 415-8