The Drug-Induced Respiratory Disease Website and App
Frequency - Incidence
Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases
Evidence level/grade
Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic
Rechallenge can lead to near-fatal or fatal relapse of AE/ILD
Publications
Hydrochlorothiazide-induced systemic capillary leak.
The American journal of emergency medicine 2020 Feb 19;; — 2020 Feb 19
[Severe and rare adverse reaction to hydrochlorothiazide].
Revista alergia Mexico (Tecamachalco, Puebla, Mexico : 1993) 2018 Oct-Dec;65;442-445 — 2018 Oct-Dec — 442-445
Acute allergic interstitial pneumonitis induced by hydrochlorothiazide.
CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne 1991 Jul 01;145;28-34 — 1991 Jul 01 — 28-34