The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

II.b

ARDS - Acute lung injury

Publications

Konits PH, Aisner J, Sutherland JC, Wiernik PH

Possible pulmonary toxicity secondary to vinblastine.

Cancer. 1982;50(12):2771-4

Rao SX, Ramaswamy G, Levin M, McCravey JW

Fatal acute respiratory failure after vinblastine-mitomycin therapy in lung carcinoma.

Archives of internal medicine. 1985;145(10):1905-7

Hoelzer KL, Harrison BR, Luedke SW, Luedke DW

Vinblastine-associated pulmonary toxicity in patients receiving combination therapy with mitomycin and cisplatin.

Drug intelligence & clinical pharmacy. 1986;20(4):287-9