The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

XLVIII.h

Dyspnea, unexplained otherwise

Publications

Gentzkow GD, Sullivan JY

Extracardiac adverse effects of flecainide.

The American journal of cardiology 1984 Feb 27;53;101B-105B — 1984 Feb 27 — 101B-105B

Hanston P, Evrard P, Mahieu P, Wallemacq P, Friob M, Hassoun A

Flecainide-associated interstitial pneumonitis.

Lancet (London, England) 1991 Feb 09;337;371-2 — 1991 Feb 09 — 371-2