The Drug-Induced Respiratory Disease Website and App
Frequency - Incidence
Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases
Evidence level/grade
Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic
Pulmonary vasculitis or capillaritis
Publications
Tryptophan-induced lung disease: an immunophenotypic, immunofluorescent, and electron microscopic study.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc. 1993;6(1):56-60
Pulmonary manifestations of the eosinophilia-myalgia syndrome associated with tryptophan ingestion.
Chest. 1992;101(5):1274-81