The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

V.a

Pleural effusion (uni- or bilateral) (can accompany DI-LDs)

Publications

Shore ET

L-tryptophan induced cough and pleural effusions associated with the eosinophilia-myalgia syndrome.

Chest. 1990;98(6):1540

Strongwater SL, Woda BA, Yood RA, Rybak ME, Sargent J, DeGirolami U, Smith TW, Varnis C, Allen S, Murphy K

Eosinophilia-myalgia syndrome associated with L-tryptophan ingestion. Analysis of four patients and implications for differential diagnosis and pathogenesis.

Archives of internal medicine. 1990;150(10):2178-86

Strumpf IJ, Drucker RD, Anders KH, Cohen S, Fajolu O

Acute eosinophilic pulmonary disease associated with the ingestion of L-tryptophan-containing products.

Chest. 1991;99(1):8-13

Williamson MR, Eidson M, Rosenberg RD, Williamson SL

Eosinophilia-myalgia syndrome: findings on chest radiographs in 18 patients.

Radiology. 1991;180(3):849-52

Campagna AC, Blanc PD, Criswell LA, Clarke D, Sack KE, Gold WM, Golden JA

Pulmonary manifestations of the eosinophilia-myalgia syndrome associated with tryptophan ingestion.

Chest. 1992;101(5):1274-81