The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

I.c

Eosinophilic pneumonia (pulmonary infiltrates and eosinophilia)

Publications

Grangeia Tde A, Schweller M, Paschoal IA, Zambon L, Pereira MC

[Acute respiratory failure as a manifestation of eosinophilia-myalgia syndrome associated with L-tryptophan intake].

Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia 2007 Nov-Dec;33;747-51 — 2007 Nov-Dec — 747-51

Tazelaar HD, Myers JL, Drage CW, King TE, Aguayo S, Colby TV

Pulmonary disease associated with L-tryptophan-induced eosinophilic myalgia syndrome. Clinical and pathologic features.

Chest 1990 May;97;1032-6 — 1990 May — 1032-6

Strumpf IJ, Drucker RD, Anders KH, Cohen S, Fajolu O

Acute eosinophilic pulmonary disease associated with the ingestion of L-tryptophan-containing products.

Chest 1991 Jan;99;8-13 — 1991 Jan — 8-13