The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

XLIII.x

Obliterative bronchiolitis (a pattern consistent with) (see also IVn, XVx)

Publications

Demaziere A, Maugars Y, Chollet S, Prost A

Non-fatal bronchiolitis obliterans possibly associated with tiopronin. A case report with long-term follow-up.

British journal of rheumatology 1993 Feb;32;172-4 — 1993 Feb — 172-4

Sigaud M, Maugars Y, Maisonneuve H, Prost A

[Tiopronin in 69 cases of rheumatoid polyarthritis treated earlier with D-penicillamine].

Revue du rhumatisme et des maladies osteo-articulaires 1988 Apr 30;55;467-71 — 1988 Apr 30 — 467-71

Sany J, Combe B, Verdie-Petibon D, Tagemouati A, Daures JP

[Long-term tolerability of tiopronin (Acadione) in the treatment of rheumatoid arthritis. Apropos of 140 personal cases].

Revue du rhumatisme et des maladies osteo-articulaires 1990 Feb;57;105-11 — 1990 Feb — 105-11