The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

LI.a

Left or biventricular dysfunction/failure

Publications

Karaa?aç M, Ery?lmaz MK

Pazopanib-induced fatal heart failure in a patient with unresectable soft tissue sarcoma and review of literature.

Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners 2019 Sep 23;;1078155219875797 — 2019 Sep 23 — 1078155219875797

Skubitz KM

Cardiotoxicity Monitoring in Patients Treated with Tyrosine Kinase Inhibitors.

The oncologist 2019 Apr 10;; — 2019 Apr 10

Wang H, Rodriguez-Pla A, Campagna A

Rapid and life-threatening heart failure induced by pazopanib.

BMJ case reports 2018 Aug 16;2018; — 2018 Aug 16