The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

I.a

Pneumonitis (ILD), acute and/or severe (may cause ARDS)

A few cases of ILD allegedly ascribed to tacrolimus with a 24-38 mortality rate reported mostly in japanese RA patients. Causality unassesseable. No case in the west

Publications

Sasaki T, Nakamura W, Inokuma S, Matsubara E

Characteristic features of tacrolimus-induced lung disease in rheumatoid arthritis patients.

Clinical rheumatology 2016 Feb;35;541-5 — 2016 Feb — 541-5

Kanzaki T, Kawahata K, Kanda H, Fujio K, Kubo K, Akahira L, Michishita K, Eri T, Yamamoto K

Long-term therapeutic effects and safety of tacrolimus added to methotrexate in patients with rheumatoid arthritis.

Rheumatology international 2013 Apr;33;871-7 — 2013 Apr — 871-7