The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

XLVI.d

Pulmonary vasculitis or capillaritis

Publications

Denissen NH, Peters JG, Masereeuw R, Barrera P

Can sulfasalazine therapy induce or exacerbate Wegener's granulomatosis?

Scandinavian journal of rheumatology 2008 Jan-Feb;37;72-4 — 2008 Jan-Feb — 72-4

Salerno SM, Ormseth EJ, Roth BJ, Meyer CA, Christensen ED, Dillard TA

Sulfasalazine pulmonary toxicity in ulcerative colitis mimicking clinical features of Wegener's granulomatosis.

Chest 1996 Aug;110;556-9 — 1996 Aug — 556-9