The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

I.c

Eosinophilic pneumonia (pulmonary infiltrates and eosinophilia)

A characteristic complication of the drug, although a parasitic etiology needs be ruled out

Publications

Haroon M, Harney S

A case of severe pulmonary infiltration with eosinophilia (PIE) syndrome induced by sulphasalazine.

International journal of rheumatic diseases 2012 Dec;15;e150-2 — 2012 Dec — e150-2

Park JE, Hwangbo Y, Chang R, Chang YW, Jang JY, Kim BH, Dong SH, Kim HJ

[Mesalazine-induced eosinophilic pneumonia in a patient with Crohn's disease].

The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi 2009 Feb;53;116-20 — 2009 Feb — 116-20

Parry SD, Barbatzas C, Peel ET, Barton JR

Sulphasalazine and lung toxicity.

The European respiratory journal 2002 Apr;19;756-64 — 2002 Apr — 756-64

Wang KK, Bowyer BA, Fleming CR, Schroeder KW

Pulmonary infiltrates and eosinophilia associated with sulfasalazine.

Mayo Clinic proceedings 1984 May;59;343-6 — 1984 May — 343-6

Berliner S, Neeman A, Shoenfeld Y, Eldar M, Rousso I, Kadish U, Pinkhas J

Salazopyrin-induced eosinophilic pneumonia.

Respiration; international review of thoracic diseases 1980;39;119-20 — 1980 — 119-20

Jones GR, Malone DN

Sulphasalazine induced lung disease.

Thorax 1972 Nov;27;713-7 — 1972 Nov — 713-7

Eastwood M

Letter: Sulphasalazine-induced lung disease.

Lancet (London, England) 1974 Sep 14;2;659-60 — 1974 Sep 14 — 659-60

Scherpenisse J, van der Valk PD, van den Bosch JM, van Hees PA, Nadorp JH

Olsalazine as an alternative therapy in a patient with sulfasalazine-induced eosinophilic pneumonia.

Journal of clinical gastroenterology 1988 Apr;10;218-20 — 1988 Apr — 218-20

Jordan A, Cowan RE

Reversible pulmonary disease and eosinophilia associated with sulphasalazine.

Journal of the Royal Society of Medicine 1988 Apr;81;233-5 — 1988 Apr — 233-5

Cazzadori A, Braggio P, Bontempini L

Salazopyrin-induced eosinophilic pneumonia.

Respiration; international review of thoracic diseases 1985;47;158-60 — 1985 — 158-60

Assouline PS, Diot P, Janvoie B, Lemarié E, Hamon B, Asquier E, Lavandier M

[Pneumopathy due to sulfasalazopyrine. A case with a challenge test].

Revue des maladies respiratoires 1991;8;233-6 — 1991 — 233-6

Yamakado S, Yoshida Y, Yamada T, Kishida T, Kobayashi M, Nomura T

Pulmonary infiltration and eosinophilia associated with sulfasalazine therapy for ulcerative colitis: a case report and review of literature.

Internal medicine (Tokyo, Japan) 1992 Jan;31;108-13 — 1992 Jan — 108-13

Constantinidis KA

Letter: Eosinophilic pneumonia: an unusual side effect of therapy with salicylazosulfapyridine.

Chest 1976 Aug;70;315-6 — 1976 Aug — 315-6