The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

I.a

Pneumonitis (interstitial lung disease/ILD)

Publications

Uittenbogaart SB, Klemt-Kropp M

[Mesalazine and sulphasalazine for Crohn's disease: few indications, severe adverse reactions].

Nederlands tijdschrift voor geneeskunde 2011;155;A3842 — 2011 — A3842

Karmakar GC, Wong CA, Horwood F, Anderson G

Sulphasalazine lung toxicity: report of two cases.

The New Zealand medical journal 2010 Aug 13;123;86-7 — 2010 Aug 13 — 86-7