The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

I.ao

Hypersensitivity pneumonitis pattern

Publications

Uranga A, Sánchez-Ortiz M, Morell F, Cruz MJ, Muñoz X

Hypersensitivity pneumonitis due to isocyanates: lung function, clinical and radiological characteristics.

Archivos de bronconeumologia 2013 Apr;49;169-72 — 2013 Apr — 169-72

Nakashima K, Takeshita T, Morimoto K

Occupational hypersensitivity pneumonitis due to isocyanates: mechanisms of action and case reports in Japan.

Industrial health 2001 Jul;39;269-79 — 2001 Jul — 269-79

Baur X

Hypersensitivity pneumonitis (extrinsic allergic alveolitis) induced by isocyanates.

The Journal of allergy and clinical immunology 1995 May;95;1004-10 — 1995 May — 1004-10

Charles J, Bernstein A, Jones B, Jones DJ, Edwards JH, Seal RM, Seaton A

Hypersensitivity pneumonitis after exposure to isocyanates.

Thorax 1976 Apr;31;127-36 — 1976 Apr — 127-36