The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

XLV.b

Eosinophilic pleural effusion

Publications

Roncato-Sabéran M, Hustache-Mathieu L, Hoen B

Eosinophilic pleural effusion caused by simvastatin after 13 years of exposure.

European journal of internal medicine 2006 Oct;17;450 — 2006 Oct — 450

Khosla R, Butman AN, Hammer DF

Simvastatin-induced lupus erythematosus.

Southern medical journal 1998 Sep;91;873-4 — 1998 Sep — 873-4

De Groot RE, Willems LN, Dijkman JH

Interstitial lung disease with pleural effusion caused by simvastin.

Journal of internal medicine 1996 Apr;239;361-3 — 1996 Apr — 361-3