The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

I.a

Pneumonitis (ILD)

Publications

Salmeron S, Brenot F, Rain B, Peuchemaur M, Herve P, Simonneau G, Duroux P, Rouveix B

Maprotiline and pulmonary alveolitis.

Annals of internal medicine 1988 Nov 01;109;758-9 — 1988 Nov 01 — 758-9

Salmeron S, Brochard L, Rain B, Herve P, Brenot F, Simonneau G, Duroux P

Early neutrophil alveolitis after rechallenge in drug induced alveolitis.

Thorax 1988 Aug;43;647-8 — 1988 Aug — 647-8