The Drug-Induced Respiratory Disease Website and App
Frequency - Incidence
Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases
Evidence level/grade
Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic
Path: Foreign body deposits/granulomatous reaction
May involve distant organs beyond the lung, notably if PFO is present (PMID 30513554)
Publications
Lung complications of prescription drug abuse.
Cleveland Clinic journal of medicine. 2018;85(12):910-911
Systemic Dissemination of Injected Foreign Material.
Journal of forensic sciences. 2019;64(4):1245-1247
An Unusual and Fatal Cause of Miliary Nodules on Chest Radiography.
Journal of clinical medicine. 2018;7(7)
Pulmonary Foreign-Body Granulomatosis.
The New England journal of medicine. 2017;377(13):1273
A Case of Pulmonary Foreign Body Granulomatosis Secondary to Intravenous Injection of Acetaminophen/Oxycodone.
Military medicine. 2016;181(10):e1404-e1406
Granulomatous lung disease: an approach to the differential diagnosis.
Archives of pathology & laboratory medicine. 2010;134(5):667-90