The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

L.e

Metabolic acidosis (incl. lactic acidosis/-gap). May cause hyperpnea/dyspnea

v.i.z. lactic acidosis

Publications

Tomar RP, Vasudevan R

Metabolic acidosis due to inhaled salbutamol toxicity: A hazardous side effect complicating management of suspected cases of acute severe asthma.

Medical journal, Armed Forces India 2012 Jul;68;242-4 — 2012 Jul — 242-4

Saxena R, Marais G

Salbutamol: beware of the paradox!

BMJ case reports 2010 Sep 29;2010; — 2010 Sep 29

Rodrigo GJ, Rodrigo C

Elevated plasma lactate level associated with high dose inhaled albuterol therapy in acute severe asthma.

Emergency medicine journal : EMJ 2005 Jun;22;404-8 — 2005 Jun — 404-8

Girgis M, Milner Q

A rare side-effect of intravenous salbutamol.

Anaesthesia 2004 Feb;59;196-7 — 2004 Feb — 196-7

Maury E, Ioos V, Lepecq B, Guidet B, Offenstadt G

A paradoxical effect of bronchodilators.

Chest 1997 Jun;111;1766-7 — 1997 Jun — 1766-7