The Drug-Induced Respiratory Disease Website and App
Frequency - Incidence
Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases
Evidence level/grade
Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic
Metabolic acidosis (incl. lactic acidosis/-gap). May cause hyperpnea/dyspnea
v.i.z. lactic acidosis
Publications
Metabolic acidosis due to inhaled salbutamol toxicity: A hazardous side effect complicating management of suspected cases of acute severe asthma.
Medical journal, Armed Forces India. 2012;68(3):242-4
Salbutamol: beware of the paradox!
BMJ case reports. 2010;2010
Elevated plasma lactate level associated with high dose inhaled albuterol therapy in acute severe asthma.
Emergency medicine journal : EMJ. 2005;22(6):404-8
A rare side-effect of intravenous salbutamol.
Anaesthesia. 2004;59(2):196-7
A paradoxical effect of bronchodilators.
Chest. 1997;111(6):1766-7