The Drug-Induced Respiratory Disease Website and App
Frequency - Incidence
Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases
Evidence level/grade
Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic
Alveolar hemorrhage (AH), diffuse AH (DAH)
Likelihood and causality disputed (PMID 25343207)
Publications
Sevoflurane-Induced Diffuse Alveolar Hemorrhage Following Strabismus Surgery: A Rare Event in the Emergency Department.
The Journal of emergency medicine 2026 Jul;86 — 2026 Jul — 39-44
Diffuse alveolar hemorrhage induced by inhaled Sevoflurane. Case report and literature review.
Respiratory medicine case reports 2023;45;101906 — 2023 — 101906
Sevoflurane-Induced Diffuse Alveolar Hemorrhage.
Archive of clinical cases 2023;10;29-31 — 2023 — 29-31
A case of diffuse alveolar hemorrhage after orthognathic surgery: Case report with the literature review'.
Nigerian journal of clinical practice 2022 Jun;25;967-970 — 2022 Jun — 967-970
Diffuse Alveolar Hemorrhage After Orotracheal Extubation Probably Induced by Sevoflurane Inhalation.
Archivos de bronconeumologia 2021 Jan 28;; — 2021 Jan 28
Diffuse alveolar hemorrhage, anesthesia, and cannabis.
Annals of the American Thoracic Society 2014 Oct;11;1338-9 — 2014 Oct — 1338-9
Diffuse alveolar hemorrhage induced by sevoflurane.
Annals of the American Thoracic Society 2014 Jun;11;853-5 — 2014 Jun — 853-5