The Drug-Induced Respiratory Disease Website and App

Herbals - Dietary botanical therapy - Health products/food - Plants

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

I.b

Pneumonitis (ILD), acute and/or severe (may cause ARDS)

Causality assessment wide ranging

Publications

Enomoto Y, Nakamura Y, Enomoto N, Fujisawa T, Inui N, Suda T

Japanese herbal medicine-induced pneumonitis: A review of 73 patients.

Respiratory investigation 2017 03;55;138-144 — 2017 03 — 138-144

Miyazaki K, Satoh H, Watanabe H, Shiozawa T, Tamura T, Kawaguchi M, Hizawa N

A case study of bofutsushosan-induced pulmonary injury in a patient: Case report.

Biomedical reports 2016 Dec;5;758-760 — 2016 Dec — 758-760