The Drug-Induced Respiratory Disease Website and App
Frequency - Incidence
Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases
Evidence level/grade
Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic
Barotrauma (incl. pneumothorax, pneumomediastinum, interstitial ephysema...)
Publications
Toledo Del Castillo B, Gordillo I, Rubio García E, Fernández Lafever SN, Gonzalez Cortés R, Urbano Villaescusa J, López González J, Solana García MJ, López-Herce Cid J
Diffuse persistent pulmonary interstitial emphysema secondary to mechanical ventilation in bronchiolitis.
BMC pulmonary medicine 2016 11 03;16;139 — 2016 11 03 — 139