The Drug-Induced Respiratory Disease Website and App
Frequency - Incidence
Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases
Evidence level/grade
Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic
Major/massive hemoptysis
Publications
Transbronchial lung cryobiopsy: prospective safety evaluation and 90-day mortality after a standardized examination protocol.
Therapeutic advances in respiratory disease 2022 Jan-Dec;16;17534666221077562 — 2022 Jan-Dec — 17534666221077562
High Complication Rate after Introduction of Transbronchial Cryobiopsy into Clinical Practice at an Academic Medical Center.
Annals of the American Thoracic Society 2017 Jun;14;851-857 — 2017 Jun — 851-857
Diagnostic Yield and Complications of Transbronchial Lung Cryobiopsy for Interstitial Lung Disease. A Systematic Review and Metaanalysis.
Annals of the American Thoracic Society 2016 10;13;1828-1838 — 2016 10 — 1828-1838