The Drug-Induced Respiratory Disease Website and App
Frequency - Incidence
Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases
Evidence level/grade
Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic
Pulmonary edema, noncardiogenic (NCPE)
Publications
Noncardiogenic pulmonary edema immediately following rapid protamine administration.
The Annals of pharmacotherapy 1999 Sep;33;927-30 — 1999 Sep — 927-30
Noncardiogenic pulmonary edema and rhabdomyolsis after protamine administration in a patient with unrecognized McArdle's disease.
Anesthesiology 1999 Jul;91;303-5 — 1999 Jul — 303-5
Protamine-induced fulminating non-cardiogenic pulmonary edema following cardiopulmonary bypass.
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 1996;10;463-6 — 1996 — 463-6