The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

IV.a

Bronchospasm - Wheezing - Asthma

Publications

Fishburne JI Jr, Brenner WE, Braaksma JT, Hendricks CH

Bronchospasm complicating intravenous prostaglandin F 2a for therapeutic abortion.

Obstetrics and gynecology. 1972;39(6):892-6

Cooley DM, Glosten B, Roberts JR, Eppes PD, Barnes RB

Bronchospasm after intramuscular 15-methyl prostaglandin F2 alpha and endotracheal intubation in a nonasthmatic patient.

Anesthesia and analgesia. 1991;73(1):87-9