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The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

II.a

Pulmonary edema, noncardiogenic (NCPE)

Publications

Khan NA, Khan RA, Tonelli AR, Highland KB, Chaisson NF, Jacob M, Renapurkar R, Dweik RA, Heresi GA

Pulmonary Edema Following Initiation of Parenteral Prostacyclin Therapy for Pulmonary Arterial Hypertension: A Retrospective Study.

Chest. 2019;156(1):45-52

Ogawa A, Miyaji K, Yamadori I, Shinno Y, Miura A, Kusano KF, Ito H, Date H, Matsubara H

Safety and efficacy of epoprostenol therapy in pulmonary veno-occlusive disease and pulmonary capillary hemangiomatosis.

Circulation journal : official journal of the Japanese Circulation Society. 2012;76(7):1729-36

von Schnakenburg C, Peuster M, Norozi K, Roebl M, Maibohm M, Wessel A, Fink C

Acute pulmonary edema caused by epoprostenol infusion in a child with scimitar syndrome and pulmonary hypertension.

Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies. 2003;4(1):111-4

Gugnani MK, Pierson C, Vanderheide R, Girgis RE

Pulmonary edema complicating prostacyclin therapy in pulmonary hypertension associated with scleroderma: a case of pulmonary capillary hemangiomatosis.

Arthritis and rheumatism. 2000;43(3):699-703

Farber HW, Graven KK, Kokolski G, Korn JH

Pulmonary edema during acute infusion of epoprostenol in a patient with pulmonary hypertension and limited scleroderma.

The Journal of rheumatology. 1999;26(5):1195-6

Humbert M, Maître S, Capron F, Rain B, Musset D, Simonneau G

Pulmonary edema complicating continuous intravenous prostacyclin in pulmonary capillary hemangiomatosis.

American journal of respiratory and critical care medicine. 1998;157(5 Pt 1):1681-5

Palmer SM, Robinson LJ, Wang A, Gossage JR, Bashore T, Tapson VF

Massive pulmonary edema and death after prostacyclin infusion in a patient with pulmonary veno-occlusive disease.

Chest. 1998;113(1):237-40