The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

IV.a

Bronchospasm - Wheezing - Asthma

Publications

Short PM, Williamson PA, Anderson WJ, Lipworth BJ

Randomized placebo-controlled trial to evaluate chronic dosing effects of propranolol in asthma.

American journal of respiratory and critical care medicine. 2013;187(12):1308-14

Shepherd D, Adams S, Wargon O, Jaffe A

Childhood wheeze while taking propranolol for treatment of infantile hemangiomas.

Pediatric pulmonology. 2012;47(7):713-5

van der Woude HJ, Zaagsma J, Postma DS, Winter TH, van Hulst M, Aalbers R

Detrimental effects of beta-blockers in COPD: a concern for nonselective beta-blockers.

Chest. 2005;127(3):818-24

Shah PK, Lakhotia M, Gupta A, Mehta S, Borana G, Gupta SK

Effect of beta-blockers on ventilatory function in smokers and non smokers.

The Journal of the Association of Physicians of India. 1993;41(9):573-5

Patakas D, Argiropoulou V, Louridas G, Tsara V

Beta-blockers in bronchial asthma: effect of propranolol and pindolol on large and small airways.

Thorax. 1983;38(2):108-12

Stephen SA

Unwanted effects of propranolol.

The American journal of cardiology. 1966;18(3):463-72