The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

IV.a

Bronchospasm - Wheezing - Asthma

Publications

Short PM, Williamson PA, Anderson WJ, Lipworth BJ

Randomized placebo-controlled trial to evaluate chronic dosing effects of propranolol in asthma.

American journal of respiratory and critical care medicine 2013 Jun 15;187;1308-14 — 2013 Jun 15 — 1308-14

Shepherd D, Adams S, Wargon O, Jaffe A

Childhood wheeze while taking propranolol for treatment of infantile hemangiomas.

Pediatric pulmonology 2012 Jul;47;713-5 — 2012 Jul — 713-5

van der Woude HJ, Zaagsma J, Postma DS, Winter TH, van Hulst M, Aalbers R

Detrimental effects of beta-blockers in COPD: a concern for nonselective beta-blockers.

Chest 2005 Mar;127;818-24 — 2005 Mar — 818-24

Shah PK, Lakhotia M, Gupta A, Mehta S, Borana G, Gupta SK

Effect of beta-blockers on ventilatory function in smokers and non smokers.

The Journal of the Association of Physicians of India 1993 Sep;41;573-5 — 1993 Sep — 573-5

Patakas D, Argiropoulou V, Louridas G, Tsara V

Beta-blockers in bronchial asthma: effect of propranolol and pindolol on large and small airways.

Thorax 1983 Feb;38;108-12 — 1983 Feb — 108-12

Stephen SA

Unwanted effects of propranolol.

The American journal of cardiology 1966 Sep;18;463-72 — 1966 Sep — 463-72