The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

II.a

Pulmonary edema, noncardiogenic (NCPE)

Publications

Sloand EM, Thompson BT

Propranolol-induced pulmonary edema and shock in a patient with pheochromocytoma.

Archives of internal medicine. 1984;144(1):173-4

Auzépy P, Boukara N, Richard C, Giudicelli JF

[Acute poisoning caused by beta blockers in the adult. Apropos of 7 cases].

Annales de cardiologie et d'angeiologie. 1983;32(4):253-8

Greenblatt DJ, Koch-Weser J

Adverse reactions to propranolol in hospitalized medical patients: a report from the Boston Collaborative Drug Surveillance Program.

American heart journal. 1973;86(4):478-84

Desai SP, Pierce EC Jr, Fleming TC

Severe hypertension, propranolol, and acute pulmonary edema.

Critical care medicine. 1987;15(8):799-800