The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

I.a

Pneumonitis (interstitial lung disease/ILD)

Publications

Cioffi V, Di Napoli G, Tozzi P, Martelli S, Bruno K, Longo A, Buso H, Pugliese F, Milito C

Non-Infectious Pneumonitis and Acute Respiratory Distress Syndrome in a Patient on Ustekinumab Treatment: Case Report and Literature Review.

Life (Basel, Switzerland) 2024 Mar 16;14; — 2024 Mar 16

Despotes KA, Vigeland CL

Stelara struck: a case of noninfectious pneumonitis secondary to ustekinumab.

BMC pulmonary medicine 2022 Jul 19;22;280 — 2022 Jul 19 — 280

Matsumoto Y, Abe N, Tobita R, Kawakami H, Nakayama H, Setoguchi Y, Tsuboi R, Okubo Y

The risk of interstitial lung disease during biological treatment in Japanese patients with psoriasis.

Clinical and experimental dermatology 2020 Oct;45;853-858 — 2020 Oct — 853-858

Sorger C, Simon JC, Treudler R

[Drug-induced interstitial lung disease (DILD) during treatment with ustekinumab].

Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete 2019 Dec 02;; — 2019 Dec 02

Brinker A, Cheng C, Chan V

Association of Noninfectious Pneumonia With Ustekinumab Use.

JAMA dermatology 2018 Dec 12;; — 2018 Dec 12

Hayashi M, Igarashi A, Okamura K, Suzuki T

Paradoxical exacerbation of latent interstitial pneumonia by secukinumab in a patient with psoriasis vulgaris.

The British journal of dermatology 2019 Mar;180;684-685 — 2019 Mar — 684-685

Lee SG, An JH, Kim DH, Yoon MS, Lee HJ

A Case of Interstitial Lung Disease and Autoimmune Thyroiditis Associated with Ustekinumab.

Acta dermato-venereologica 2019 Mar 01;99;331-332 — 2019 Mar 01 — 331-332

Ali A, Chertoff J, Harden C, Wakefield D, Wynne J

Stop Being So Sensitive: An Exceptionally Rare Report of Ustekinumab-Induced Sub-acute Hypersensitivity Pneumonitis.

Turkish journal of anaesthesiology and reanimation 2017 Oct;45;313-317 — 2017 Oct — 313-317

Kikuchi S, Umezawa Y, Hayashi M, Yanaba K, Fukuchi O, Ito T, Asahina A, Saeki H, Nakagawa H

Interstitial pneumonia in two patients with psoriasis during ustekinumab treatment.

The Journal of dermatology 2016 Jun;43;712-3 — 2016 Jun — 712-3