The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

I.b

Pneumonitis (interstitial lung disease/ILD)

Publications

Cioffi V, Di Napoli G, Tozzi P, Martelli S, Bruno K, Longo A, Buso H, Pugliese F, Milito C

Non-Infectious Pneumonitis and Acute Respiratory Distress Syndrome in a Patient on Ustekinumab Treatment: Case Report and Literature Review.

Life (Basel, Switzerland). 2024;14(3)

Despotes KA, Vigeland CL

Stelara struck: a case of noninfectious pneumonitis secondary to ustekinumab.

BMC pulmonary medicine. 2022;22(1):280

Matsumoto Y, Abe N, Tobita R, Kawakami H, Nakayama H, Setoguchi Y, Tsuboi R, Okubo Y

The risk of interstitial lung disease during biological treatment in Japanese patients with psoriasis.

Clinical and experimental dermatology. 2020;45(7):853-858

Sorger C, Simon JC, Treudler R

[Drug-induced interstitial lung disease (DILD) during treatment with ustekinumab].

Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete. 2020;71(4):309-312

Brinker A, Cheng C, Chan V

Association of Noninfectious Pneumonia With Ustekinumab Use.

JAMA dermatology. 2019;155(2):221-224

Hayashi M, Igarashi A, Okamura K, Suzuki T

Paradoxical exacerbation of latent interstitial pneumonia by secukinumab in a patient with psoriasis vulgaris.

The British journal of dermatology. 2019;180(3):684-685

Lee SG, An JH, Kim DH, Yoon MS, Lee HJ

A Case of Interstitial Lung Disease and Autoimmune Thyroiditis Associated with Ustekinumab.

Acta dermato-venereologica. 2019;99(3):331-332

Ali A, Chertoff J, Harden C, Wakefield D, Wynne J

Stop Being So Sensitive: An Exceptionally Rare Report of Ustekinumab-Induced Sub-acute Hypersensitivity Pneumonitis.

Turkish journal of anaesthesiology and reanimation. 2017;45(5):313-317

Kikuchi S, Umezawa Y, Hayashi M, Yanaba K, Fukuchi O, Ito T, Asahina A, Saeki H, Nakagawa H

Interstitial pneumonia in two patients with psoriasis during ustekinumab treatment.

The Journal of dermatology. 2016;43(6):712-3