The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

III.a

Alveolar hemorrhage (AH), diffuse AH (DAH)

Publications

Sakamoto S, Kaburaki K, Gochyo K, Ishida F, Sakaguchi S, Satoh K, Sano G, Sugino K, Isobe K, Kurosaki A, Homma S

[Azithromycin-induced diffuse alveolar hemorrhage].

Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society 2009 Apr;47;337-41 — 2009 Apr — 337-41