The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

I.c

Eosinophilic pneumonia (pulmonary infiltrates and eosinophilia)

Publications

Brooks BJ, Hendler NB, Alvarez S, Ancalmo N, Grinton SF

Delayed life-threatening pneumonitis secondary to procarbazine.

American journal of clinical oncology 1990 Jun;13;244-6 — 1990 Jun — 244-6

Ecker MD, Jay B, Keohane MF

Procarbazine lung.

AJR. American journal of roentgenology 1978 Sep;131;527-8 — 1978 Sep — 527-8