The Drug-Induced Respiratory Disease Website and App
Frequency - Incidence
Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases
Evidence level/grade
Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic
Path: NSIP-fibrotic pattern
Publications
Reversible lung fibrosis in a 6-year-old girl after long term nitrofurantoin treatment.
BMC pulmonary medicine 2020 Nov 26;20;313 — 2020 Nov 26 — 313
Chronic nitrofurantoin-induced lung disease.
Mayo Clinic proceedings 2005 Oct;80;1298-302 — 2005 Oct — 1298-302
Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 22-1974.
The New England journal of medicine 1974 Jun 06;290;1309-14 — 1974 Jun 06 — 1309-14