The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

VI.d

Pleural/pericardial effusion, ANA positive (DI lupus)

Publications

Sarzi-Puttini P, Atzeni F, Capsoni F, Lubrano E, Doria A

Drug-induced lupus erythematosus.

Autoimmunity 2005 Nov;38;507-18 — 2005 Nov — 507-18

Rubin RL

Drug-induced lupus.

Toxicology 2005 Apr 15;209;135-47 — 2005 Apr 15 — 135-47

KAPLAN JM, WACHTEL HL, CZARNECKI SW, SAMPSON JJ

LUPUS-LIKE ILLNESS PRECIPITATED BY PROCAINAMIDE HYDROCHLORIDE.

JAMA 1965 May 10;192;444-7 — 1965 May 10 — 444-7

LADD AT

Procainamide-induced lupus erythematosus.

The New England journal of medicine 1962 Dec 27;267;1357-8 — 1962 Dec 27 — 1357-8

Ohtani Y, Sumi Y, Hisauchi K, Sawada M, Miyake S, Yamashita Y, Mitunaga K, Yoshizawa Y

[Procainamide-induced lupus in a patient with bilateral pleural effusion].

Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society 1998 Jun;36;535-40 — 1998 Jun — 535-40

Dubois EL

Procainamide induction of a systemic lupus erythematosus-like syndrome. Presentation of six cases, review of the literature, and analysis and followup of reported cases.

Medicine 1969 May;48;217-28 — 1969 May — 217-28

Mohindra SK, Udeani GO, Abrahamson D

Cardiac tamponade associated with drug-induced systemic lupus erythematosus.

Critical care medicine 1989 Sep;17;961-2 — 1989 Sep — 961-2

Ghose MK

Pericardial tamponade. A presenting manifestation of procainamide-induced lupus erythematosus.

The American journal of medicine 1975 Apr;58;581-5 — 1975 Apr — 581-5

Sonnhag C, Karlsson E, Hed J

Procainamide-induced lupus erythematosus-like syndrome in relation to acetylator phenotype and plasma levels of procainamide.

Acta medica Scandinavica 1979;206;245-51 — 1979 — 245-51

Kaplan AI, Zakher F, Sabin S

Drug-induced lupus erythematosus with in vivo lupus erythematosus cells in pleural fluid.

Chest 1978 Jun;73;875-6 — 1978 Jun — 875-6