The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

V.d

Pleural/pericardial effusion, ANA positive (DI lupus)

Publications

Sarzi-Puttini P, Atzeni F, Capsoni F, Lubrano E, Doria A

Drug-induced lupus erythematosus.

Autoimmunity. 2005;38(7):507-18

Rubin RL

Drug-induced lupus.

Toxicology. 2005;209(2):135-47

KAPLAN JM, WACHTEL HL, CZARNECKI SW, SAMPSON JJ

LUPUS-LIKE ILLNESS PRECIPITATED BY PROCAINAMIDE HYDROCHLORIDE.

JAMA. 1965;192:444-7

LADD AT

Procainamide-induced lupus erythematosus.

The New England journal of medicine. 1962;267:1357-8

Ohtani Y, Sumi Y, Hisauchi K, Sawada M, Miyake S, Yamashita Y, Mitunaga K, Yoshizawa Y

[Procainamide-induced lupus in a patient with bilateral pleural effusion].

Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society. 1998;36(6):535-40

Dubois EL

Procainamide induction of a systemic lupus erythematosus-like syndrome. Presentation of six cases, review of the literature, and analysis and followup of reported cases.

Medicine. 1969;48(3):217-28

Mohindra SK, Udeani GO, Abrahamson D

Cardiac tamponade associated with drug-induced systemic lupus erythematosus.

Critical care medicine. 1989;17(9):961-2

Ghose MK

Pericardial tamponade. A presenting manifestation of procainamide-induced lupus erythematosus.

The American journal of medicine. 1975;58(4):581-5

Sonnhag C, Karlsson E, Hed J

Procainamide-induced lupus erythematosus-like syndrome in relation to acetylator phenotype and plasma levels of procainamide.

Acta medica Scandinavica. 1979;206(4):245-51

Kaplan AI, Zakher F, Sabin S

Drug-induced lupus erythematosus with in vivo lupus erythematosus cells in pleural fluid.

Chest. 1978;73(6):875-6