The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

I.ab

Delayed ILD, -pneumonitis, -fibrosis

Publications

Yamakawa H, Yoshida M, Takagi M, Kuwano K

Late-onset methotrexate-induced pneumonitis with neutrophilia in bronchoalveolar lavage fluid.

BMJ case reports 2014 Sep 29;2014; — 2014 Sep 29

Elsasser S, Dalquen P, Soler M, Perruchoud AP

Methotrexate-induced pneumonitis: appearance four weeks after discontinuation of treatment.

The American review of respiratory disease 1989 Oct;140;1089-92 — 1989 Oct — 1089-92