The Drug-Induced Respiratory Disease Website and App

Disinfectants (humidifier disinfectants used in the home or occupational setting)

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

XLI.e

ARDS - Acute lung injury

Publications

Ryu SH, Park DU, Lee E, Park S, Lee SY, Jung S, Hong SB, Park J, Hong SJ

Humidifier disinfectant and use characteristics associated with lung injury in Korea.

Indoor air 2019 Sep;29;735-747 — 2019 Sep — 735-747

Lee E, Son SK, Yoon J, Cho HJ, Yang SI, Jung S, Do KH, Cho YA, Lee SY, Park DU, Hong SJ

Two Cases of Chloromethylisothiazolinone and Methylisothiazolinone-associated Toxic Lung Injury.

Journal of Korean medical science 2018 Apr 16;33;e119 — 2018 Apr 16 — e119

Nemery B, Hoet PH

Humidifier disinfectant-associated interstitial lung disease and the Ardystil syndrome.

American journal of respiratory and critical care medicine 2015 Jan 01;191;116-7 — 2015 Jan 01 — 116-7