The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

XLII.a

Alveolar hemorrhage (AH), diffuse AH (DAH)

Publications

Polman AJ, van der Werf TS, Tiebosch AT, Zijlstra JG

Early-onset phenytoin toxicity mimicking a renopulmonary syndrome.

The European respiratory journal 1998 Feb;11;501-3 — 1998 Feb — 501-3

Yermakov VM, Hitti IF, Sutton AL

Necrotizing vasculitis associated with diphenylhydantoin: two fatal cases.

Human pathology 1983 Feb;14;182-4 — 1983 Feb — 182-4