The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

LV.be

Imaging: Intrathoracic lymph node enlargement

Publications

Tsuchiya K, Suzuki Y, Yasui H, Hozumi H, Karayama M, Furuhashi K, Enomoto N, Fujisawa T, Nakamura Y, Inui N, Baba S, Suda T

Methotrexate-associated Lymphoproliferative Disorder with Diffuse Ground-Glass Opacities.

American journal of respiratory and critical care medicine 2019 Apr 15;199;1031-1033 — 2019 Apr 15 — 1031-1033

Filip DJ, Logue GL, Harle TS, Farrar WH

Pulmonary and hepatic complications of methotrexate therapy of psoriasis.

JAMA 1971 May 03;216;881-2 — 1971 May 03 — 881-2

Sostman HD, Matthay RA, Putman CE, Smith GJ

Methotrexate-induced pneumonitis.

Medicine 1976 Sep;55;371-88 — 1976 Sep — 371-88