The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

XII.l

Cardiac arrhythmias or dysrhythmias (AF, VT, VF, TdP)

Publications

Hopkins ME, MacKenzie-Ross RV

Case Report: The risks associated with chronic theophylline therapy and measures designed to improve monitoring and management.

BMC pharmacology & toxicology. 2016;17:13

Kraaijenbrink BV, van den Hoek HL, Nowitzky RJ, Wilms EB

[Auto-intoxication with an illegal slimming product].

Nederlands tijdschrift voor geneeskunde. 2015;159:A9016

Barnes PJ

Theophylline.

American journal of respiratory and critical care medicine. 2013;188(8):901-6