The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

I.a

Pneumonitis (interstitial lung disease/ILD)

Publications

Tseng D, Mason XL, Neilan TG, Sullivan RJ

Cardiogenic Shock and Respiratory Failure in a Patient With Metastatic Melanoma Receiving Trametinib Therapy.

The oncologist 2016 09;21;1136-7 — 2016 09 — 1136-7

Giraud V, Longvert C, Houlle-Crepin S, Danel C, Labrune S, Camus P, Saiag P, Chinet T

Relapsing pneumonitis due to two distinct inhibitors of the MAPK/ERK pathway: report of a case.

BMC cancer 2015 Oct 19;15;732 — 2015 Oct 19 — 732