The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

XLV.a

Pleural effusion (uni- or bilateral) (can accompany DI-LDs)

Publications

Kastelik JA, Aziz I, Greenstone MA, Thompson R, Morice AH

Pergolide-induced lung disease in patients with Parkinson's disease.

Respiratory medicine 2002 Jul;96;548-50 — 2002 Jul — 548-50

Danoff SK, Grasso ME, Terry PB, Flynn JA

Pleuropulmonary disease due to pergolide use for restless legs syndrome.

Chest 2001 Jul;120;313-6 — 2001 Jul — 313-6

Varsano S, Gershman M, Hamaoui E

Pergolide-induced dyspnea, bilateral pleural effusion and peripheral edema.

Respiration; international review of thoracic diseases 2000;67;580-2 — 2000 — 580-2