The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

IV.a

Bronchospasm - Wheezing - Asthma

Publications

Principi N, Marchisio P, Onorato J, Gabiano C, Galli L, Caselli D, Morandi B, Campelli A, Clerici M, Gattinara GC

Long-term administration of aerosolized pentamidine as primary prophylaxis against Pneumocystis carinii pneumonia in infants and children with symptomatic human immunodeficiency virus infection. The Italian Pediatric Collaborative Study Group on Pentamidi

Journal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association 1996 Jun 01;12;158-63 — 1996 Jun 01 — 158-63

Saukkonen K, Garland R, Koziel H

Aerosolized pentamidine as alternative primary prophylaxis against Pneumocystis carinii pneumonia in adult hepatic and renal transplant recipients.

Chest 1996 May;109;1250-5 — 1996 May — 1250-5

Mustafa MM, Pappo A, Cash J, Winick NJ, Buchanan GR

Aerosolized pentamidine for the prevention of Pneumocystis carinii pneumonia in children with cancer intolerant or allergic to trimethoprim/sulfamethoxazole.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1994 Feb;12;258-61 — 1994 Feb — 258-61

Acute pulmonary effects of aerosolized pentamidine. A randomized controlled study. Toronto Aerosolized Pentamidine Study (TAPS) Group.

Chest 1990 Oct;98;907-10 — 1990 Oct — 907-10

Katzman M, Meade W, Iglar K, Rachlis A, Berger P, Chan CK

High incidence of bronchospasm with regular administration of aerosolized pentamidine.

Chest 1992 Jan;101;79-81 — 1992 Jan — 79-81

Gearhart MO, Bhutani MS

Intravenous pentamidine-induced bronchospasm.

Chest 1992 Dec;102;1891-2 — 1992 Dec — 1891-2