The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

XLVIII.a

Diaphragm/inspiratory muscle weakness/paralysis (w/wo ARF)

From Conium maculatum

Publications

Karakasi MV, Tologkos S, Papadatou V, Raikos N, Lambropoulou M, Pavlidis P

Conium maculatum intoxication: Literature review and case report on hemlock poisoning.

Forensic science review 2019 Jan;31;23-36 — 2019 Jan — 23-36

Lung DD, Scott BJ, Wu AH, Gerona RR

Prolonged ventilatory failure and flaccid quadriparesis after ingestion of poison hemlock.

Muscle & nerve 2013 Nov;48;823-7 — 2013 Nov — 823-7