The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

XLVIII.a

Diaphragm/inspiratory muscle weakness/paralysis (w/wo ARF)

Publications

Stevens MA, Yeaney GA, Lacomis D

42-year-old man with discoid lupus and progressive weakness.

Brain pathology (Zurich, Switzerland) 2009 Jan;19;153-6 — 2009 Jan — 153-6

Siddiqui AK, Huberfeld SI, Weidenheim KM, Einberg KR, Efferen LS

Hydroxychloroquine-induced toxic myopathy causing respiratory failure.

Chest 2007 Feb;131;588-90 — 2007 Feb — 588-90

Seguin P, Camus C, Leroy JP, Le Tulzo Y, Jouannic I, Thomas R

Respiratory failure associated with hydroxychloroquine neuromyopathy.

European neurology 1995;35;236-7 — 1995 — 236-7