The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

I.b

Pneumonitis (interstitial lung disease/ILD)

Publications

Shettar SP, Chattopadhyay C, Wolstenholme RJ, Swinson DR

Diffuse alveolitis on a small dose of penicillamine.

British journal of rheumatology. 1984;23(3):220-4

Eastmond CJ

Diffuse alveolitis as complication of penicillamine treatment for rheumatoid arthritis.

British medical journal. 1976;1(6024):1506

Petersen J, Møller I

Miliary pulmonary infiltrates and penicillamine.

The British journal of radiology. 1978;51(611):915-6