The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

I.b

Pneumonitis (interstitial lung disease/ILD)

Publications

Bielopolski D, Evron E, Moreh-Rahav O, Landes M, Stemmer SM, Salamon F

Paclitaxel-induced pneumonitis in patients with breast cancer: case series and review of the literature.

Journal of chemotherapy (Florence, Italy). 2017;29(2):113-117

Abulkhair O, El Melouk W

Delayed Paclitaxel-trastuzumab-induced interstitial pneumonitis in breast cancer.

Case reports in oncology. 2011;4(1):186-91

Wong P, Leung AN, Berry GJ, Atkins KA, Montoya JG, Ruoss SJ, Stockdale FE

Paclitaxel-induced hypersensitivity pneumonitis: radiographic and CT findings.

AJR. American journal of roentgenology. 2001;176(3):718-20

Fujimori K, Yokoyama A, Kurita Y, Uno K, Saijo N

Paclitaxel-induced cell-mediated hypersensitivity pneumonitis. Diagnosis using leukocyte migration test, bronchoalveolar lavage and transbronchial lung biopsy.

Oncology. 1998;55(4):340-4

Ramanathan RK, Reddy VV, Holbert JM, Belani CP

Pulmonary infiltrates following administration of paclitaxel.

Chest. 1996;110(1):289-92

Reckzeh B, Merte H, Pflüger KH, Pfab R, Wolf M, Havemann K

Severe lymphocytopenia and interstitial pneumonia in patients treated with paclitaxel and simultaneous radiotherapy for non-small-cell lung cancer.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 1996;14(4):1071-6

Goldberg HL, Vannice SB

Pneumonitis related to treatment with paclitaxel.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 1995;13(2):534-5