The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

I.a

Pneumonitis (interstitial lung disease/ILD)

Publications

Bielopolski D, Evron E, Moreh-Rahav O, Landes M, Stemmer SM, Salamon F

Paclitaxel-induced pneumonitis in patients with breast cancer: case series and review of the literature.

Journal of chemotherapy (Florence, Italy) 2017 Apr;29;113-117 — 2017 Apr — 113-117

Abulkhair O, El Melouk W

Delayed Paclitaxel-trastuzumab-induced interstitial pneumonitis in breast cancer.

Case reports in oncology 2011 Apr 02;4;186-91 — 2011 Apr 02 — 186-91

Wong P, Leung AN, Berry GJ, Atkins KA, Montoya JG, Ruoss SJ, Stockdale FE

Paclitaxel-induced hypersensitivity pneumonitis: radiographic and CT findings.

AJR. American journal of roentgenology 2001 Mar;176;718-20 — 2001 Mar — 718-20

Fujimori K, Yokoyama A, Kurita Y, Uno K, Saijo N

Paclitaxel-induced cell-mediated hypersensitivity pneumonitis. Diagnosis using leukocyte migration test, bronchoalveolar lavage and transbronchial lung biopsy.

Oncology 1998 Jul-Aug;55;340-4 — 1998 Jul-Aug — 340-4

Ramanathan RK, Reddy VV, Holbert JM, Belani CP

Pulmonary infiltrates following administration of paclitaxel.

Chest 1996 Jul;110;289-92 — 1996 Jul — 289-92

Reckzeh B, Merte H, Pflüger KH, Pfab R, Wolf M, Havemann K

Severe lymphocytopenia and interstitial pneumonia in patients treated with paclitaxel and simultaneous radiotherapy for non-small-cell lung cancer.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1996 Apr;14;1071-6 — 1996 Apr — 1071-6

Goldberg HL, Vannice SB

Pneumonitis related to treatment with paclitaxel.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1995 Feb;13;534-5 — 1995 Feb — 534-5